PIN1 expression contributes to hepatic carcinogenesis.

@article{Pang2006PIN1EC,
  title={PIN1 expression contributes to hepatic carcinogenesis.},
  author={Richard Pang and Terence Kin-Wah Lee and Kwan Man and Ronnie Tung-ping Poon and S-T Fan and Yin Yee Kwong and Eric Tse},
  journal={The Journal of pathology},
  year={2006},
  volume={210 1},
  pages={
          19-25
        }
}
The phospho-Ser/Thr-Pro specific prolyl-isomerase PIN1 is over-expressed in more than 50% of hepatocellular carcinomas (HCCs). To investigate its potential oncogenicity, we over-expressed PIN1 in a non-transformed human liver cell line MIHA. This resulted in up-regulation of beta-catenin and cyclin D1, leading to anchorage-independent growth in soft agar and tumorigenicity in nude mice. To further validate the role of PIN1 in hepatocarcinogenesis, PIN was suppressed by RNA interference (siRNA… CONTINUE READING

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