PIN domain of Nob1p is required for D-site cleavage in 20S pre-rRNA.

  title={PIN domain of Nob1p is required for D-site cleavage in 20S pre-rRNA.},
  author={Alessandro Fatica and David Tollervey and Mensur Dlakic},
  volume={10 11},
Nob1p (Yor056c) is essential for processing of the 20S pre-rRNA to the mature 18S rRNA. It is part of a pre-40S ribosomal particle that is transported to the cytoplasm and subsequently cleaved at the 3' end of mature 18S rRNA (D-site). Nob1p is also reported to participate in proteasome biogenesis, and it was therefore unclear whether its primary activity is in ribosome synthesis. In this work, we describe a homology model of the PIN domain of Nob1p, which structurally mimics Mg(2+)-dependent… CONTINUE READING

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