PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

@article{BrasMaristany2016PIM1KR,
  title={PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer},
  author={F. Bras{\'o}-Maristany and S. Filosto and S. Catchpole and Rebecca Marlow and J. Quist and E. Francesch-Domenech and Darren A. Plumb and Leila Zakka and P. Gazińska and G. Liccardi and P. Meier and A. Gris-Oliver and M. Cheang and Anna Perdrix-Rosell and M. Shafat and {\'E}. No{\"e}l and Nirmesh Patel and Kristen McEachern and M. Scaltriti and P. Castel and Farzana Noor and R. Buus and S. Mathew and J. Watkins and V. Serra and P. Marra and A. Grigoriadis and A. Tutt},
  journal={Nature Medicine},
  year={2016},
  volume={22},
  pages={1303-1313}
}
  • F. Brasó-Maristany, S. Filosto, +25 authors A. Tutt
  • Published 2016
  • Biology, Medicine
  • Nature Medicine
  • Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. [...] Key Result TNBC cells, but not nonmalignant mammary epithelial cells, were dependent on PIM1 for proliferation and protection from apoptosis. PIM1 knockdown reduced expression of the anti-apoptotic factor BCL2, and dynamic BH3 profiling of apoptotic priming revealed that PIM1 prevents mitochondrial-mediated apoptosis in TNBC cell lines.Expand Abstract
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