PIM1 kinase inhibitors induce radiosensitization in non-small cell lung cancer cells.

@article{Kim2013PIM1KI,
  title={PIM1 kinase inhibitors induce radiosensitization in non-small cell lung cancer cells.},
  author={Wanyeon Kim and Hyesook Youn and Taewoo Kwon and Jihoon Kang and EunGi Kim and Beomseok Son and Hee Jung Yang and Youngmi Jung and Buhyun Youn},
  journal={Pharmacological research},
  year={2013},
  volume={70 1},
  pages={90-101}
}
Radiotherapy plays a critical role in the treatment of non-small cell lung cancer (NSCLC). However, radioresistance is a major barrier against increasing the efficiency of radiotherapy for NSCLC. To understand the mechanisms underlying NSCLC radioresistance, we previously focused on the potential involvement of PIM1, PRAS40, FOXO3a, 14-3-3, and protein phosphatases. Among these proteins, PIM1 functioned as an oncogene and was found to act as a crucial mediator in radioresistant NSCLC cells… CONTINUE READING

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