PIM1 kinase as a target for cancer therapy.

  title={PIM1 kinase as a target for cancer therapy.},
  author={Anna Lena Merkel and Eric Meggers and Matthias Ocker},
  journal={Expert opinion on investigational drugs},
  volume={21 4},
INTRODUCTION Inhibition of protein kinases has become a standard of modern clinical oncology. PIM1 belongs to a novel class of serine/threonine kinases with distinct molecular and biochemical features regulating various oncogenic pathways, for example hypoxia response, cell cycle progression and apoptosis resistance. PIM1 is overexpressed in human cancer diseases and has been associated with metastasis and overall treatment response; in experimental models, inhibition of PIM1 suppressed cell… CONTINUE READING
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