Corpus ID: 201719549

PIM 1 kinase regulates cell death , tumor growth and chemotherapy response in triple-negative breast cancer

@inproceedings{BrasMaristany2017PIM1K,
  title={PIM 1 kinase regulates cell death , tumor growth and chemotherapy response in triple-negative breast cancer},
  author={F. Bras{\'o}-Maristany and S. Filosto and S. Catchpole and Rebecca Marlow and Jelmar and Quist and E. Francesch-Domenech and Darren A. Plumb and Leila Zakka and P. Gazińska and G. Liccardi and P. Meier and A. Gris-Oliver and M. Cheang and Anna. and Perdrix-Rosell and M. Shafat and {\'E}. No{\"e}l and Nirmesh Patel and Kristen McEachern and M. Scaltriti and P. Castel and Farzana Noor and R. Buus and S. Mathew and Johnathan and Watkins and V. Serra and P. Marra and A. Grigoriadis and A. Tutt},
  year={2017}
}
  • F. Brasó-Maristany, S. Filosto, +28 authors A. Tutt
  • Published 2017
  • Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Here we identified increased copy number and expression of the PIM1 proto-oncogene in genomic data sets of patients with TNBC. TNBC cells, but not nonmalignant mammary epithelial cells, were Correspondence should be addressed to A.N.T (andrew.tutt@icr.ac.uk). Accession codes. Gene Expression Omnibus: raw data from the gene expression microarray for the Guy’s Hospital TNBC-enriched data set are available… CONTINUE READING
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