PIM-1 gene RNA interference induces growth inhibition and apoptosis of prostate cancer cells and suppresses tumor progression in vivo.

@article{Zhang2010PIM1GR,
  title={PIM-1 gene RNA interference induces growth inhibition and apoptosis of prostate cancer cells and suppresses tumor progression in vivo.},
  author={Tong Zhang and Xiaoguang Zhang and Kejia Ding and Kuo Yang and Zhihong Zhang and Yong Xu},
  journal={Journal of surgical oncology},
  year={2010},
  volume={101 6},
  pages={
          513-9
        }
}
BACKGROUND The goal of this study was to investigate the roles of PIM-1 in prostate cancer (CaP) cell proliferation and apoptosis, and to assess the potential of PIM-1 as a target for CaP therapy. METHODS Using RNAi technology, we knocked down the expression of PIM-1 in PC-3 cell. After siRNA transfection, cell morphology, cell proliferation, cell cycle, and apoptosis rate were analyzed. PIM-1 siRNA with Lipofectamine were injected into xenograft models to evaluate its therapeutic effect… CONTINUE READING
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SHOWING 1-10 OF 19 REFERENCES

The serine/threonine kinase Pim-1.

  • The international journal of biochemistry & cell biology
  • 2005
VIEW 1 EXCERPT

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002