PIKE GTPase Signaling and Function

@article{Ahn2005PIKEGS,
  title={PIKE GTPase Signaling and Function},
  author={Jee-Yin Ahn and Keqiang Ye},
  journal={International Journal of Biological Sciences},
  year={2005},
  volume={1},
  pages={44 - 50}
}
PIKE (PI 3-Kinase Enhancer) is a recently identified brain specific nuclear GTPase, which binds PI 3-kinase and stimulates its lipid kinase activity. Nerve growth factor treatment leads to PIKE activation by triggering the nuclear translocation of phospholipase C-gamma1 (PLC-gamma1), which acts as a physiologic guanine nucleotide exchange factor (GEF) for PIKE through its SH3 domain. To date, three forms of PIKE have been characterized: PIKE-S, PIKE-L and PIKE-A. PIKE-S is initially identified… CONTINUE READING

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View 3 Excerpts
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References

Publications referenced by this paper.
Showing 1-10 of 47 references

PIKE (PI 3-kinase-enhancer)-A GTPase stimulates Akt activity and regulates cancer cell invasion

JY Ahn
J Biol Chem • 2004
View 5 Excerpts
Highly Influenced

GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

Molecular and cellular biology • 2003
View 6 Excerpts
Highly Influenced

Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2000
View 7 Excerpts
Highly Influenced

A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N

K Ye, et al. Pike
Cell • 2000
View 5 Excerpts
Highly Influenced

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 1 Excerpt

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