PIKE GTPase Signaling and Function

  title={PIKE GTPase Signaling and Function},
  author={Jee-Yin Ahn and Keqiang Ye},
  journal={International Journal of Biological Sciences},
  pages={44 - 50}
PIKE (PI 3-Kinase Enhancer) is a recently identified brain specific nuclear GTPase, which binds PI 3-kinase and stimulates its lipid kinase activity. Nerve growth factor treatment leads to PIKE activation by triggering the nuclear translocation of phospholipase C-gamma1 (PLC-gamma1), which acts as a physiologic guanine nucleotide exchange factor (GEF) for PIKE through its SH3 domain. To date, three forms of PIKE have been characterized: PIKE-S, PIKE-L and PIKE-A. PIKE-S is initially identified… CONTINUE READING


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