PIKE A Nuclear GTPase that Enhances PI3Kinase Activity and Is Regulated by Protein 4.1N

  title={PIKE A Nuclear GTPase that Enhances PI3Kinase Activity and Is Regulated by Protein 4.1N},
  author={Keqiang Ye and K. Joseph Hurt and Frederick Y. Wu and Ming Fang and Hongbo Robert Luo and Jenny Jimmy Hong and Seth Blackshaw and Christopher Ferris and Solomon H Snyder},
While cytoplasmic PI3Kinase (PI3K) is well characterized, regulation of nuclear PI3K has been obscure. A novel protein, PIKE (PI3Kinase Enhancer), interacts with nuclear PI3K to stimulate its lipid kinase activity. PIKE encodes a 753 amino acid nuclear GTPase. Dominant-negative PIKE prevents the NGF enhancement of PI3K and upregulation of cyclin D1. NGF treatment also leads to PIKE interactions with 4.1N, which has translocated to the nucleus, fitting with the initial identification of PIKE… CONTINUE READING
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