PIK3CAH1047R and Her2 initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling

Abstract

Human breast cancers that have HER2 amplification/overexpression frequently carry PIK3CA mutations, and are often associated with a worse prognosis. However, the role of PIK3CA mutations in the initiation and maintenance of these breast cancers remains elusive. In the present study, we generated a compound mouse model that genetically mimics HER2-positive… (More)
DOI: 10.1038/onc.2015.377

Topics

6 Figures and Tables

Cite this paper

@inproceedings{Cheng2016PIK3CAH1047RAH, title={PIK3CAH1047R and Her2 initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling}, author={Hailing Cheng and Pixu Liu and Carolynn E Ohlson and Erbo Xu and Lynn K. Symonds and A. Isabella and William J. Muller and Nancy U. Lin and Ian Krop and Thomas M Roberts and Eric P. Winer and Carlos L. Arteaga and J. Zhao}, booktitle={Oncogene}, year={2016} }