PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.

@article{Saal2005PIK3CAMC,
  title={PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.},
  author={Lao H. Saal and Karolina Holm and Matthew Maurer and Lorenzo Memeo and Tao Su and Xiao-mei Wang and Jennifer S Yu and Per Malmstr{\"o}m and Mahesh M. Mansukhani and Jens Enoksson and Hanina Hibshoosh and {\AA}ke Borg and Ramon Parsons},
  journal={Cancer research},
  year={2005},
  volume={65 7},
  pages={2554-9}
}
Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway either through loss of PTEN or mutation of the catalytic subunit alpha of PI3K (PIK3CA) occurs frequently in human cancer. We identified PIK3CA mutations in 26% of 342 human breast tumor samples and cell lines at about equal frequency in tumor stages I to IV. To investigate the relationship… CONTINUE READING