PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma

@article{Yamamoto2011PIK3CAMA,
  title={PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma},
  author={Sohei Yamamoto and Hitoshi Tsuda and Masashi Takano and Seiichi Tamai and Osamu Matsubara},
  journal={Virchows Archiv},
  year={2011},
  volume={460},
  pages={77-87}
}
Somatic mutations of PIK3CA and ARID1A are the most common genetic alterations observed in ovarian clear cell adenocarcinomas (CCA). In a previous report, we showed that PIK3CA gene mutations and loss of ARID1A expression occur early during the development of CCA. In the present study, using direct genomic DNA sequencing for exons 9 and 20 of PIK3CA and immunohistochemistry for ARID1A protein expression, we analyzed the association of these molecular alterations with various clinicopathological… CONTINUE READING
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