PIK3CA in breast carcinoma: a mutational analysis of sporadic and hereditary cases.

@article{Michelucci2009PIK3CAIB,
  title={PIK3CA in breast carcinoma: a mutational analysis of sporadic and hereditary cases.},
  author={Angela Michelucci and Claudio di Cristofano and Azzurra Lami and Paola Collecchi and Adelaide M Caligo and Nicola Liberta Decarli and Martina Leopizzi and Paolo Aretini and Gloria Bertacca and Romana Prosperi Porta and Sergio Ricci and Carlo Della Rocca and Giorgio Stanta and Generoso Bevilacqua and Andrea Cavazzana},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  year={2009},
  volume={18 4},
  pages={200-5}
}
The PI3K-Akt cascade is a key signaling pathway involved in cell proliferation, survival, and growth. Activating PIK3CA mutations have been reported in breast carcinoma (BC). The aim of this study was to characterize the PIK3CA mutations at exons 9 and 20 in a series of 176 sporadic and 22 hereditary BCs and to correlate the results with clinicopathologic parameters and survival. In sporadic BC, 68 missense mutations were detected. PIK3CA mutations were significantly associated with ER+ in HER2… CONTINUE READING