PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer.


PURPOSE PIK3CA and PTEN mutations are prevalent in colorectal cancer and potential markers of response to mitogen-activated protein/extracellular signal-regulated kinase inhibitors and anti-EGF receptor antibody therapy. Relationships between phosphoinositide 3-kinase (PI3K) pathway mutation, clinicopathologic characteristics, molecular features, and… (More)
DOI: 10.1158/1078-0432.CCR-12-3614


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