PII signal transduction proteins are ATPases whose activity is regulated by 2-oxoglutarate

  title={PII signal transduction proteins are ATPases whose activity is regulated by 2-oxoglutarate},
  author={M. Radchenko and J. Thornton and M. Merrick},
  journal={Proceedings of the National Academy of Sciences},
  pages={12948 - 12953}
  • M. Radchenko, J. Thornton, M. Merrick
  • Published 2013
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • PII proteins are one of the most widespread families of signal transduction proteins in nature, being ubiquitous throughout bacteria, archaea, and plants. In all these organisms, PII proteins coordinate many facets of nitrogen metabolism by interacting with and regulating the activities of enzymes, transcription factors, and membrane transport proteins. The primary mode of signal perception by PII proteins derives from their ability to bind the effector molecules 2-oxoglutarate (2-OG) and ATP… CONTINUE READING
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