Corpus ID: 235312679

PII: S0925-4773(99)00045-3

@inproceedings{Seoa1999PIIS,
  title={PII: S0925-4773(99)00045-3},
  author={Hee-Chan Seoa and Jennifer Curtissb and Marek Mlodzikb and Anders Fjosea},
  year={1999}
}
The vertebrate Six genes are homologues of the Drosophila homeobox gene sine oculis (so), which is essential for development of the entire visual system. Here we describe two new Six genes in Drosophila, D-Six3 and D-Six4, which encode proteins with strongest similarity to vertebrate Six3 and Six4, respectively. In addition, we report the partial sequences of 12 Six gene homologues from several lower vertebrates and show that the class of Six proteins can be subdivided into three major families… Expand

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References

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TLDR
The expression domains of the four genes in the developing rostral brain of mouse embryos at a developmental stage, day 10 post coitum, seem to be continuous regions contained within each other in the sequence Emxl < Emx2 < Otxl< Otx2. Expand
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.
TLDR
The isolation of a sequence-related gene referred to as Six3 is reported, which is one of the most anterior homeobox gene reported to date and supports the idea that mammals and insects share control genes such as eyeless/Pax6 and also possibly other members of the regulatory cascade required for eye morphogenesis. Expand
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TLDR
The deduced Six7 protein shares less than 68% sequence identity with the other known zebrafish Six3-like proteins, but the embryonic expression patterns have highly conserved features. Expand
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Observations suggest that some of the Six family genes can regulate the same target genes, and the so‐homologous region of each Six family protein has specific DNA binding activity. Expand
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TLDR
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Two zebrafish genes, six3 and six6, that are closely related to the murine Six3 gene are reported and direct correspondence between six3/six6 expression boundaries and the optic vesicles indicate essential roles in defining the eye primordia. Expand
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Analysis of three independent Sey alleles is reported and it is shown that indeed this gene is mutated and that the mutations would predictably interrupt gene function. Expand
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