PIDD orchestrates translesion DNA synthesis in response to UV irradiation

@article{Logette2011PIDDOT,
  title={PIDD orchestrates translesion DNA synthesis in response to UV irradiation},
  author={Emmanuelle Logette and Sonia Schuepbach-Mallepell and Matthew J. Eckert and X H Leo and Bastienne Jaccard and Claudia Manzl and Aubry Tardivel and Andreas Villunger and Manfredo Quadroni and Olivier Gaide and Jennifer Tschopp},
  journal={Cell Death and Differentiation},
  year={2011},
  volume={18},
  pages={1036-1045}
}
PIDD has been implicated in survival and apoptotic pathways in response to DNA damage, and a role for PIDD was recently identified in non-homologous end-joining (NHEJ) repair induced by γ-irradiation. Here, we present an interaction of PIDD with PCNA, first identified in a proteomics screen. PCNA has essential functions in DNA replication and repair following UV irradiation. Translesion synthesis (TLS) is a process that prevents UV irradiation-induced replication blockage and is characterized… CONTINUE READING
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