PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans.

@article{Albuquerque2014PID1IA,
  title={PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans.},
  author={Bruno F M de Albuquerque and Maartje J. Luteijn and Ricardo J Cordeiro Rodrigues and Petra van Bergeijk and Selma Waaijers and Lucas J. T. Kaaij and Holger Klein and Mike Boxem and Ren{\'e} F Ketting},
  journal={Genes & development},
  year={2014},
  volume={28 7},
  pages={683-8}
}
The Piwi-piRNA pathway represents a small RNA-based mechanism responsible for the recognition and silencing of invading DNA. Biogenesis of piRNAs (21U-RNAs) is poorly understood. In Caenorhabditis elegans, the piRNA-binding Argonaute protein PRG-1 is the only known player acting downstream from precursor transcription. From a screen aimed at the isolation of piRNA-induced silencing-defective (Pid) mutations, we identified, among known Piwi pathway components, PID-1 as a novel player. PID-1 is a… CONTINUE READING