PICOT : A Trx-and Grx-Like Protein in Search of a Function


The PKC-interacting cousin of thioredoxin (PICOT) protein was discovered based on its ability to bind PKC in human T lymphocytes. Overexpression of PICOT was found to impose negative regulatory effects on PKC -dependent functions. This included the inhibition of PKC -dependent activation of c-Jun Nterminal kinase (JNK) and the activator protein 1 (AP-1) and… (More)


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