PIC Activation through Functional Interplay between Mediator and TFIIH.

@article{Malik2017PICAT,
  title={PIC Activation through Functional Interplay between Mediator and TFIIH.},
  author={Sohail Malik and Henrik Molina and Zhu Xue},
  journal={Journal of molecular biology},
  year={2017},
  volume={429 1},
  pages={48-63}
}
The multiprotein Mediator coactivator complex functions in large part by controlling the formation and function of the promoter-bound preinitiation complex (PIC), which consists of RNA polymerase II and general transcription factors. However, precisely how Mediator impacts the PIC, especially post-recruitment, has remained unclear. Here, we have studied Mediator effects on basal transcription in an in vitro transcription system reconstituted from purified components. Our results reveal a close… CONTINUE READING
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