PIC Activation through Functional Interplay between Mediator and TFIIH.

  title={PIC Activation through Functional Interplay between Mediator and TFIIH.},
  author={Sohail Malik and Henrik Molina and Zhu Xue},
  journal={Journal of molecular biology},
  volume={429 1},
The multiprotein Mediator coactivator complex functions in large part by controlling the formation and function of the promoter-bound preinitiation complex (PIC), which consists of RNA polymerase II and general transcription factors. However, precisely how Mediator impacts the PIC, especially post-recruitment, has remained unclear. Here, we have studied Mediator effects on basal transcription in an in vitro transcription system reconstituted from purified components. Our results reveal a close… CONTINUE READING
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  • F. C. Holstege, D. Tantin
  • Carey, P.C. van der Vliet, H.T. Timmers, The…
  • 1995
Highly Influential
18 Excerpts

Structure of a complete Mediator–RNA polymerase II pre-initiation

  • P. J. Robinson
  • 2016
Highly Influential
8 Excerpts

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