PIAS3 suppresses acute graft-versus-host disease by modulating effector T and B cell subsets through inhibition of STAT3 activation.

@article{Lee2014PIAS3SA,
  title={PIAS3 suppresses acute graft-versus-host disease by modulating effector T and B cell subsets through inhibition of STAT3 activation.},
  author={Sung-Hee Lee and Su-Jin Moon and Min-Jung Park and Eun-Kyung Kim and Young-Mee Moon and Mi-La Cho},
  journal={Immunology letters},
  year={2014},
  volume={160 1},
  pages={79-88}
}
Graft-versus-host disease (GVHD) caused by transplanted donor T cells remains the major obstacle of allogeneic bone marrow transplantation (BMT). Previous reports have suggested that IL-17-producing helper T (Th17) cells mediate the development of acute GVHD (aGVHD). Protein inhibitor of activated STAT3 (PIAS) inhibits the activity of the transcription factor STAT3, which is a pivotal transcription factor for Th17 differentiation. To elucidate whether PIAS3 could inhibit the development of… CONTINUE READING