PIAS3 enhances the transcriptional activity of HIF-1α by increasing its protein stability.

@article{Nakagawa2016PIAS3ET,
  title={PIAS3 enhances the transcriptional activity of HIF-1α by increasing its protein stability.},
  author={Koji Nakagawa and Toshihisa Kohara and Yasuko Uehata and Yui Miyakawa and Maremi Sato-Ueshima and Naoto Okubo and Masahiro Asaka and Hiroshi Takeda and Masanobu Kobayashi},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={469 3},
  pages={470-6}
}
The transcription factor hypoxia-inducible factor-1 (HIF-1) functions as a master regulator of hypoxic response by inducing the transcription of various genes responsible for cellular adaptation to hypoxia. In this study, we investigated the effects of protein inhibitor of activated STAT3 (PIAS3), a small ubiquitin-related modifier (SUMO) E3 ligase, on HIF… CONTINUE READING