PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity


Interferon (IFN) activates the signal transducer and activator of transcription (STAT) pathway to regulate immune responses. The protein inhibitor of activated STAT (PIAS) family has been suggested to negatively regulate STAT signaling. To understand the physiological function of PIAS1, we generated Pias1−/− mice. Using PIAS1-deficient cells, we show that… (More)
DOI: 10.1038/ni1104

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