PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein.

@article{Matsuura2005PIASPA,
  title={PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein.},
  author={Tetsuo Matsuura and Yohei Shimono and Kumi Kawai and Hideki Murakami and Takeshi Urano and Yasumasa Niwa and Hidemi Goto and Masahide Takahashi},
  journal={Experimental cell research},
  year={2005},
  volume={308 1},
  pages={65-77}
}
Ret finger protein (RFP) is a nuclear protein that is highly expressed in testis and in various tumor cell lines. RFP functions as a transcriptional repressor and associates with Enhancer of Polycomb 1 (EPC1), a member of the Polycomb group proteins, and Mi-2beta, a main component of the nucleosome remodeling and deacetylase (NuRD) complex. We show that RFP binds with PIAS (protein inhibitor of activated STAT) proteins, PIAS1, PIAS3, PIASxalpha and PIASy at their carboxyl-terminal region and is… CONTINUE READING

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