PI3Ks in lymphocyte signaling and development.

  title={PI3Ks in lymphocyte signaling and development.},
  author={Klaus Okkenhaug and David A Fruman},
  journal={Current topics in microbiology and immunology},
Lymphocyte development and function are regulated by tyrosine kinase and G-protein coupled receptors. Each of these classes of receptors activates phosphoinositide 3-kinase (PI3K). In this chapter, we summarize current understanding of how PI3K contributes to key aspects of the adaptive immune system.