PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis.

@article{Ili2011PI3KtargetedTC,
  title={PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis.},
  author={Nina Ili{\'c} and Tamara Utermark and Hans Ragnar Widlund and Thomas M Roberts},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 37},
  pages={E699-708}
}
The PI3K pathway is frequently activated in cancer; therefore, considerable effort is focused on identifying compounds that can inhibit specific pathway components, particularly the hallmark oncogene PIK3CA. Although targeted inhibition of a cancer survival gene holds significant promise, there are concerns that drug resistance may emerge within the cancerous cells, thus limiting clinical efficacy. Using genetically defined human mammary epithelial cells, we evolved resistance to the PI3K… CONTINUE READING

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