PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion.

@article{Hu2012PI3KPP,
  title={PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion.},
  author={Jun Hu and Yu Shuang Chai and Yugang Wang and Michael M. Kheir and Huiying Li and Zhiyi Yuan and Hongjiao Wan and Dongming Xing and Fan Lei and Lijun Du},
  journal={European journal of pharmacology},
  year={2012},
  volume={674 2-3},
  pages={
          132-42
        }
}
Berberine is a candidate clinical neuroprotective agent against ischemic stroke. In the present study, we examined the influence of the PI3K/Akt pathway in mediating the anti-apoptotic effects of berberine. Oxygen-glucose deprivation and reoxygenation of nerve growth factor-differentiated PC12 cells and primary neurons, and bilateral common carotid artery occlusion in mice were used as in vitro and in vivo ischemia models. We found that the anti-apoptotic effects of berberine against ischemia… CONTINUE READING

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