PI3K p110β subunit in leptin receptor expressing cells is required for the acute hypophagia induced by endotoxemia

@inproceedings{Borges2016PI3KPS,
  title={PI3K p110β subunit in leptin receptor expressing cells is required for the acute hypophagia induced by endotoxemia},
  author={Beatriz de Carvalho Borges and David Garc{\'i}a-Galiano and Rodrigo Cesar Rorato and Lucila L. K. Elias and Carol F Elias},
  booktitle={Molecular metabolism},
  year={2016}
}
OBJECTIVE Hypophagia and increased energy expenditure under inflammatory conditions, such as that observed after bacterial lipopolysaccharide (LPS) administration, are associated with leptin secretion. The hypophagic effect of leptin depends in part on the activation of PI3K signaling pathway. However, the role of PI3K in the endotoxemia-induced hypophagia has not been determined. METHODS In an attempt to examine the functional contribution of the PI3K pathway in hypophagia and weight loss… CONTINUE READING