PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors.

@article{Meng2011PI3KME,
  title={PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors.},
  author={Xiaoting Meng and Miguel Arocena and Josef M. Penninger and Fred H. Gage and Min Zhao and Bing Song},
  journal={Experimental neurology},
  year={2011},
  volume={227 1},
  pages={210-7}
}
Correct guidance of the migration of neural progenitor cells (NPCs) is essential for the development and repair of the central nervous system (CNS). Electric field (EF)-guided migration, electrotaxis, has been observed in many cell types. We report here that, in applied EFs of physiological magnitude, embryonic and adult NPCs show marked electrotaxis, which is dependent on the PI3K/Akt pathway. The electrotaxis was also evidenced by ex vivo investigation that transplanted NPCs migrated… CONTINUE READING
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