PI3K is required for the physical interaction and functional inhibition of NF-κB by β-catenin in colorectal cancer cells.

@article{Liu2013PI3KIR,
  title={PI3K is required for the physical interaction and functional inhibition of NF-κB by β-catenin in colorectal cancer cells.},
  author={Jingyi Liu and Yueling Liao and Kewei Ma and Yonglu Wang and Guoxiang Zhang and Rongcun Yang and Jiong Deng},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={434 4},
  pages={760-6}
}
Activation of β-catenin and PI3K pathways are crucial for the oncogenesis of colorectal cancer (CRC). It remains controversial whether these two pathways function independently or cooperatively in the development and progression of CRC. We showed previously that β-catenin inhibited NF-κB activation by interacting with p65 and this inhibitory interaction involved an unidentified cellular protein. In this study, we found that the PI3K effect on NF-κB activity is dependent on the level of… CONTINUE READING
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