PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein.

  title={PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein.},
  author={Zhenqi Zhu and Xin He and Carla Johnson and John W Stoops and Amanda E Eaker and David S. Stoffer and Aaron Bell and Reza Zarnegar and Marie Defrances},
  journal={Biochemical and biophysical research communications},
  volume={358 1},
Signaling initiated by Class Ia phosphatidylinositol-3-kinases (PI3Ks) is essential for cell proliferation and survival. We discovered a novel protein we call PI3K interacting protein 1 (PIK3IP1) that shares homology with the p85 regulatory PI3K subunit. Using a variety of in vitro and cell based assays, we demonstrate that PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Our studies suggest that PIK3IP1 is a new type of PI3K regulator. 

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