PI3K integrates the action of insulin and leptin on hypothalamic neurons.

@article{Xu2005PI3KIT,
  title={PI3K integrates the action of insulin and leptin on hypothalamic neurons.},
  author={Allison Wanting Xu and Christopher B. Kaelin and Kiyoshi Takeda and Shizuo Akira and Michael J. Schwartz and Gregory S Barsh},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 4},
  pages={951-8}
}
Central control of energy balance depends on the ability of proopiomelanocortin (POMC) or agouti-related protein (Agrp) hypothalamic neurons to sense and respond to changes in peripheral energy stores. Leptin and insulin have been implicated as circulating indicators of adiposity, but it is not clear how changes in their levels are perceived or integrated by individual neuronal subtypes. We developed mice in which a fluorescent reporter for PI3K activity is targeted to either Agrp or POMC… CONTINUE READING