PI3K induces B-cell development and regulates B cell identity

  title={PI3K induces B-cell development and regulates B cell identity},
  author={Hend Abdelrasoul and Markus Werner and Corinna S. Setz and Klaus Okkenhaug and Hassan Jumaa},
  booktitle={Scientific Reports},
Phosphoinositide-3 kinase (PI3K) signaling is important for the survival of numerous cell types and class IA of PI3K is specifically required for the development of B cells but not for T cell development. Here, we show that class IA PI3K-mediated signals induce the expression of the transcription factor Pax5, which plays a central role in B cell commitment and differentiation by activating the expression of central B cell-specific signaling proteins such as SLP-65 and CD19. Defective class IA… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 58 references

Transcriptional control of adipose lipid handling by IRF4

  • J Eguchi
  • Cell metabolism 13,
  • 2011

Similar Papers

Loading similar papers…