PI3K class IB pathway.

  title={PI3K class IB pathway.},
  author={Simon R. Andrews and Len R. Stephens and Phillip T. Hawkins},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2007 407},
Class I phosphoinositide 3-kinases (PI3Ks) are well-established signal transduction enzymes that play an important role in the mechanisms by which a wide variety of cell surface receptors control several cellular functions, including cellular growth, division, survival, and movement. Class IB PI3K (also known as PI3Kgamma) allows fast-acting, heterotrimeric GTP-binding protein-coupled receptors to access this pathway. Activation of class IB PI3K results in the rapid synthesis of… CONTINUE READING