PI3K and negative regulation of TLR signaling.

  title={PI3K and negative regulation of TLR signaling.},
  author={Taro Fukao and Shigeo Koyasu},
  journal={Trends in immunology},
  volume={24 7},
Excessive immune responses are detrimental to the host and negative feedback regulation is crucial for the maintenance of immune-system integrity. Recent studies have shown that phosphoinositide 3-kinase (PI3K) is an endogenous suppressor of interleukin-12 (IL-12) production triggered by Toll-like receptor (TLR) signaling and limits excessive Th1 polarization. Unlike IRAK-M (IL-1 receptor-associated kinase-M) and SOCS-1 (suppressor of cytokine signaling-1) that are induced by TLR signaling and… CONTINUE READING
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