PI3K and cancer: lessons, challenges and opportunities

  title={PI3K and cancer: lessons, challenges and opportunities},
  author={David A Fruman and Christian Rommel},
  journal={Nature Reviews Drug Discovery},
The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and mammalian target of rapamycin (mTOR) in cancer. However, emerging clinical data show limited single-agent activity of inhibitors targeting PI3K, AKT or mTOR at tolerated doses. One exception is the response to PI3Kδ inhibitors in chronic lymphocytic leukaemia, where a combination of cell-intrinsic and -extrinsic activities… CONTINUE READING
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