PI3K and AKT: Unfaithful Partners in Cancer

  title={PI3K and AKT: Unfaithful Partners in Cancer},
  author={Seraina Faes and Olivier Dormond and William Chi-shing Cho},
  booktitle={International journal of molecular sciences},
The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular processes. An overactivation of the pathway is frequently present in human malignancies and plays a key role in cancer progression. Hence, its inhibition has become a promising approach in cancer therapy. However, the development of resistances, such as the abrogation of negative feedback mechanisms or the activation of other proliferative signaling pathways, has considerably limited the anticancer… CONTINUE READING
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