PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury

@inproceedings{Doherty2014PI3KSA,
  title={PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury},
  author={Johnna Doherty and Amy E. Sheehan and Rachel Bradshaw and A. Nicole Fox and Tsai-Yi Lu and Marc R. Freeman},
  booktitle={PLoS biology},
  year={2014}
}
Glial cells are exquisitely sensitive to neuronal injury but mechanisms by which glia establish competence to respond to injury, continuously gauge neuronal health, and rapidly activate reactive responses remain poorly defined. Here, we show glial PI3K signaling in the uninjured brain regulates baseline levels of Draper, a receptor essential for Drosophila glia to sense and respond to axonal injury. After injury, Draper levels are up-regulated through a Stat92E-modulated, injury-responsive… CONTINUE READING
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