PI3K-GSK3 signaling regulates mammalian axon regeneration by inducing the expression of Smad1

@inproceedings{Saijilafu2013PI3KGSK3SR,
  title={PI3K-GSK3 signaling regulates mammalian axon regeneration by inducing the expression of Smad1},
  author={Saijilafu and Eun-Mi Hur and Zhongxian Jiao and Chang-Mei Liu and Wen-Lin Xu and Feng-quan Zhou},
  booktitle={Nature communications},
  year={2013}
}
In contrast to neurons in the central nervous system, mature neurons in the mammalian peripheral nervous system (PNS) can regenerate axons after injury, in part, by enhancing intrinsic growth competence. However, the signalling pathways that enhance the growth potential and induce spontaneous axon regeneration remain poorly understood. Here we reveal that phosphatidylinositol 3-kinase (PI3K) signalling is activated in response to peripheral axotomy and that PI3K pathway is required for sensory… CONTINUE READING
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