PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy.

@article{Berdichevsky2013PI3KAktSA,
  title={PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy.},
  author={Yevgeny Berdichevsky and Alexandra M Dryer and Y. H. Saponjian and Mark M Mahoney and Corrin A Pimentel and Corrina A Lucini and Marija Usenovic and Kevin J Staley},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 21},
  pages={
          9056-67
        }
}
mTOR is activated in epilepsy, but the mechanisms of mTOR activation in post-traumatic epileptogenesis are unknown. It is also not clear whether mTOR inhibition has an anti-epileptogenic, or merely anticonvulsive effect. The rat hippocampal organotypic culture model of post-traumatic epilepsy was used to study the effects of long-term (four weeks) inhibition of signaling pathways that interact with mTOR. Ictal activity was quantified by measurement of lactate production and electrical… CONTINUE READING

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