PI3K-δ inhibition using CAL-101 exerts apoptotic effects and increases doxorubicin-induced cell death in pre-B-acute lymphoblastic leukemia cells.

@article{SafaroghliAzar2017PI3KIU,
  title={PI3K-δ inhibition using CAL-101 exerts apoptotic effects and increases doxorubicin-induced cell death in pre-B-acute lymphoblastic leukemia cells.},
  author={Ava Safaroghli-Azar and Davood Bashash and Parisa Sadreazami and Majid Momeny and Seyed Hamidollah Ghaffari},
  journal={Anti-cancer drugs},
  year={2017},
  volume={28 4},
  pages={436-445}
}
The frequency of dysregulated PI3K in acute lymphoblastic leukemia (ALL) coupled with the critical role of this signaling pathway in the acquisition of chemoresistant phenotype lend compelling weight to the application of PI3K inhibitors for the treatment of ALL. In this study, we found that abrogation of the PI3K pathway using CAL-101, a selective inhibitor of PI3K p110-δ, exerts a cytotoxic effect against Nalm-6 pre-B-ALL cells. Our results showed that the growth-suppressive effect is… CONTINUE READING