PI3K: a potential therapeutic target for cancer.

  title={PI3K: a potential therapeutic target for cancer.},
  author={Yingwei Chen and Bao-can Wang and Yongtao Xiao},
  journal={Journal of cellular physiology},
  volume={227 7},
Phosphatidylinositol 3-kinase (PI3K), one member of lipid kinase family, has been demonstrated to play a key role in regulating cell proliferation, adhesion, survival, and motility. Recent studies indicate that PI3K related signaling pathway is one of the most commonly activated pathways in human cancers. Accordingly, pharmacological inhibition of key nodes in this signaling cascade has been a focus in developmental therapeutics. To date, Inhibitors targeting PI3K or nodes in this pathway, AKT… CONTINUE READING

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