PI3K/p110α inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization: potential implications for drug-eluting stent design.

@article{Holy2014PI3Kp110IS,
  title={PI3K/p110α inhibition selectively interferes with arterial thrombosis and neointima formation, but not re-endothelialization: potential implications for drug-eluting stent design.},
  author={Erik Walter Holy and Philipp Jakob and Thomas Eickner and Giovanni G Camici and Juerg Hans Beer and Alexander Akhmedov and Katrin Sternberg and Klaus-Peter Schmitz and Thomas Felix L{\"u}scher and Felix C. Tanner},
  journal={European heart journal},
  year={2014},
  volume={35 12},
  pages={808-20}
}
BACKGROUND Impaired re-endothelialization and stent thrombosis are a safety concern associated with drug-eluting stents (DES). PI3K/p110α controls cellular wound healing pathways, thereby representing an emerging drug target to modulate vascular homoeostasis after injury. METHODS AND RESULTS PI3K/p110α was inhibited by treatment with the small molecule… CONTINUE READING