PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer.

@article{Herzog2013PI3KmTORIP,
  title={PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer.},
  author={Amanda Herzog and Yansong Bian and Robert Vander Broek and Bradford D. Hall and Jamie F Coupar and Hui Huang Cheng and Anastasia L. Sowers and John Dylan Cook and James B. Mitchell and Zhong Chen and Ashok Kulkarni and Carter Van Waes},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 14},
  pages={3808-19}
}
PURPOSE Phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway activation is often associated with altered expression or mutations of PIK3CA, TP53/p73, PTEN, and TGF-β receptors (TGFBR) in head and neck squamous cell carcinomas (HNSCC). However, little is known about how these alterations affect response to PI3K/mTOR-targeted agents. EXPERIMENTAL DESIGN In this preclinical study, PI3K/Akt/mTOR signaling was characterized in nine HNSCC (UM-SCC) cell lines and human oral… CONTINUE READING
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PTEN as a prognostic and predictive PI3K/mTOR Inhibition Induces TP53 in HNSCC www.aacrjournals.org Clin Cancer Res

  • M Snietura, M Jaworska, J Mlynarczyk-Liszka, A Goraj-Zajac, W Piglowski, D Lange
  • OF11 Research. on July
  • 2013

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