PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis.

  title={PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis.},
  author={Jing Fang and Min Ding and Lily C Yang and Ling-zhi Liu and Bing-hua Jiang},
  journal={Cellular signalling},
  volume={19 12},
PI3K pathway exerts its function through its downstream molecule AKT in regulating various cell functions including cell proliferation, cell transformation, cell apoptosis, tumor growth and angiogenesis. PTEN is an inhibitor of PI3K, and its loss or mutation is common in human prostate cancer. But the direct role and mechanism of PI3K/PTEN signaling in regulating angiogenesis and tumor growth in vivo remain to be elucidated. In this study, by using chicken chorioallantoic membrane (CAM) and in… CONTINUE READING
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