PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma.

@article{Zhuo2015PI3KAktSM,
  title={PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma.},
  author={Baobiao Zhuo and Yuan Li and Zhengwei Li and Haihui Qin and Qingzeng Sun and Fengfei Zhang and Yang Shen and Yingchun Shi and Rong Wang},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={464 2},
  pages={401-6}
}
Accumulating evidence has shown that PI3K/Akt pathway is frequently hyperactivated in osteosarcoma (OS) and contributes to tumor initiation and progression. Altered phenotype of glucose metabolism is a key hallmark of cancer cells including OS. However, the relationship between PI3K/Akt pathway and glucose metabolism in OS remains largely unexplored. In this study, we showed that elevated Hexokinase-2 (HK2) expression, which catalyzes the first essential step of glucose metabolism by conversion… CONTINUE READING
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