PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.

@article{Zhou2004PI3KAktIR,
  title={PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation.},
  author={Jie Zhou and Tobias Schmid and Ronald F Frank and Bernhard Br{\"u}ne},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 14},
  pages={13506-13}
}
Hypoxia inducible factor 1 (HIF-1), a heterodimeric transcription factor composed of HIF-1alpha and HIF-1beta subunits, serves as a key regulator of metabolic adaptation to hypoxia. The amount of HIF-1alpha protein is regulated either by attenuating von Hippel-Lindau protein (pVHL)-dependent ubiquitination and subsequent 26 S proteasomal degradation or by enhancing cap-dependent mRNA translation, presumably involving a phosphatidyinositol 3-kinase (PI3K)/Akt-regulated pathway. In addition, it… CONTINUE READING
71 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 71 extracted citations

Similar Papers

Loading similar papers…