PI3K/Akt inhibition and down-regulation of BCRP re-sensitize MCF7 breast cancer cell line to mitoxantrone chemotherapy

@inproceedings{KomeiliMovahhed2015PI3KAktIA,
  title={PI3K/Akt inhibition and down-regulation of BCRP re-sensitize MCF7 breast cancer cell line to mitoxantrone chemotherapy},
  author={Tahereh Komeili-Movahhed and Shamileh Fouladdel and Elmira Barzegar and Shekoufeh Atashpour and Mohammad Hossein Ghahremani and Seyed Nasser Ostad and Zahra Madjd and Ebrahim Azizi},
  booktitle={Iranian journal of basic medical sciences},
  year={2015}
}
OBJECTIVES Multidrug resistance (MDR) of cancer cells is a major obstacle to successful chemotherapy. Overexpression of breast cancer resistance protein (BCRP) is one of the major causes of MDR. In addition, it has been shown that PI3K/Akt signaling pathway involves in drug resistance. Therefore, we evaluated the effects of novel approaches including siRNA directed against BCRP and targeted therapy against PI3K/Akt signaling pathway using LY294002 (LY) to re-sensitize breast cancer MCF7 cell… CONTINUE READING