PI3K/Akt-dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells.

@article{Graham2009PI3KAktdependentTR,
  title={PI3K/Akt-dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells.},
  author={Tisheeka R. Graham and Valerie Odero-Marah and Leland W. K. Chung and Krishna C. Agrawal and Rodney Davis and Asim B. Abdel-Mageed},
  journal={The Prostate},
  year={2009},
  volume={69 2},
  pages={168-80}
}
BACKGROUND Bone morphogenetic proteins (BMPs) exert osteoinductive effects in prostate cancer (PC) via uncharacterized mechanisms. In this study, we investigated whether the nuclear transcription factor NF-kappaB, implicated in PC metastasis, is involved in transcriptional regulation and activation of BMP-2 or BMP-4/Smad signaling in PC cells. METHODS NF-kappaB inhibition was achieved by IkappaBalpha super-repressor adenoviral vector and activation was monitored by EMSA and reporter assays… CONTINUE READING
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