PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation

@article{Peltier2007PI3KAktAC,
  title={PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation},
  author={Joseph Peltier and Analeah O'Neill and David V. Schaffer},
  journal={Developmental Neurobiology},
  year={2007},
  volume={67}
}
The phosphoinositide 3‐OH kinase (PI3K)/Akt pathway has been implicated in regulating several important cellular processes, including apoptosis, survival, proliferation, and metabolism. Using both pharmacological and genetic means, we demonstrate here that PI3K/Akt plays a crucial role in the proliferation of adult hippocampal neural progenitor cells. PI3K/Akt transduces intracellular signals from multiple mitogens, including basic fibroblast growth factor (FGF‐2), Sonic hedgehog (Shh), and… 
IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade
TLDR
It is demonstrated that the Ras-related GTPase, RIT1, plays a critical role in IGF-1-dependent neurogenesis and is identified as a key component of neurogenic niche sensing, contributing to the regulation of neural stem cell homeostasis.
Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation
TLDR
It is shown that CREB is highly expressed and constitutively activated in patient glioma tissue and that this activation closely correlates with tumour grade, which may lead to improved novel combinatorial anti-tumour therapies which can complement existing PI3K-specific drugs undergoing early phase clinical trials.
PI3K‐p110‐alpha‐subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2
TLDR
The data indicate a central role of mTORC2 in survival, proliferation as well as neuronal differentiation of E16.5‐derived cortical cells and that these subtypes are under control of different PI3K isoforms.
IGF-1 Promotes Brn-4 Expression and Neuronal Differentiation of Neural Stem Cells via the PI3K/Akt Pathway
TLDR
The results demonstrated that upregulation of IGF-1 induced by hippocampal denervation injury leads to activation of the PI3K/Akt signaling pathway, which in turn gives rise to up regulation of the Brn-4 and subsequent stem cell differentiation down neuronal pathways.
Involvement of the PI3K/AKT pathway in ATP-induced proliferation of developing retinal cells in culture
Critical Role of PI3K/Akt/GSK3β in Motoneuron Specification from Human Neural Stem Cells in Response to FGF2 and EGF
TLDR
The data suggest that FGF2 and EGF affect the motor neuron fate decision in hNSCs differently through a fine tuning of the PI3K/AKT/GSK3β pathway, and that manipulation of this pathway can enhance motor neuron generation.
Ghrelin regulates cell cycle-related gene expression in cultured hippocampal neural stem cells.
TLDR
The data suggest that ghrelin targets both cell cycle positive and negative regulators to stimulate proliferation of cultured hippocampal NSCs.
Akt1 interacts with epidermal growth factor receptors and hedgehog signaling to increase stem/transit amplifying cells in the embryonic mouse cortex
TLDR
The contributions of signaling via epidermal growth factor and hedgehog receptors are addressed and it is suggested that a subset of precursors in the embryonic cortex that express an elevated level of Akt1 can respond to lower concentrations of Shh than neighboring precursor, resulting in an increase in their expression of EGFRs.
Differential regulation of proliferation and neuronal differentiation in adult rat spinal cord neural stem/progenitors by ERK1/2, Akt, and PLCγ
TLDR
This work demonstrated that the blockade of either the ERK1/2 or PLCγ signaling pathways reduced neurite branching of MAP2+ cells derived from the NSPC cultures, indicating that over time adult spinal cord NSPCs had differentiated into mostly glutamatergic neurons.
The Regulatory Mechanism of Neurogenesis by IGF-1 in Adult Mice
TLDR
It is demonstrated that IGF-1 upregulates the proliferation of NSCs by triggering MEK/ERK pathway signaling in the adult mice SGZ and SVZ through the PI3K/Akt pathway in adult mice.
...
...

References

SHOWING 1-10 OF 105 REFERENCES
A novel role for Gab2 in bFGF-mediated cell survival during retinoic acid–induced neuronal differentiation
TLDR
These findings provide the first evidence that Gab2 is an important player in neural differentiation, partly by acting downstream of bFGF to mediate survival through phosphoinositide 3 kinase–AKT.
Akt-1 Expression Level Regulates CNS Precursors
TLDR
It is suggested that expression of a high level of Akt-1 by a subpopulation of cortical progenitors biases their responses to extrinsic signals to increase their survival, proliferation, and/or self-renewal.
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling.
TLDR
It is reported that phosphoinositide 3-kinase (PI3-kinases)-dependent Akt activation is essential for Sonic Hedgehog (Shh) signaling in the specification of neuronal fates in chicken neural explants, chondrogenic differentiation of 10T1/2 cells, and Gli activation in NIH 3T3 cells.
Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors
TLDR
Findings indicate that Shh and PI3K signaling pathways converge on N-Myc to regulate neuronal precursor cell cycle progression, and provide a rationale for therapeutic targeting of PI3k signaling in medulloblastoma.
IGF-I has a direct proliferative effect in adult hippocampal progenitor cells
CREB Is a Regulatory Target for the Protein Kinase Akt/PKB*
TLDR
The results support the notion that Akt/PKB promotes cell survival, at least in part, by stimulating the expression of cellular genes via the CREB/CBP nuclear transduction pathway.
Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein
TLDR
The results suggest that the cAMP–CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors on adult neurogenesis.
Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells
TLDR
It is shown that myristoylated, active form of Akt (myr-Akt) maintained the undifferentiated phenotypes in mouse ES cells without the addition of leukemia inhibitory factor (LIF) and support the notion that PI3K/Akt signaling axis regulates ‘stemness’ in a broad spectrum of stem cell systems.
Akt Regulates Basic Helix-Loop-Helix Transcription Factor-Coactivator Complex Formation and Activity during Neuronal Differentiation
TLDR
It is proposed that Akt regulates the assembly and activity of bHLH-coactivator complexes to promote neuronal differentiation.
N-CoR controls differentiation of neural stem cells into astrocytes
TLDR
It is proposed that repression by N-CoR, modulated by opposing enzymatic activities, is a critical mechanism in neural stem cells that underlies the inhibition of glial differentiation.
...
...